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HPLC Columns for Reliable, Reproducible Method Development

GL Sciences HPLC columns deliver clean peak shape, high inertness, and reproducible results — trusted by method developers in validated methods and regulated labs.

Lot-to-Lot Reproducibility

Lot-to-Lot Reproducibility

Trusted by method developers in regulated labs — consistent performance across batches.

High Inertness

High Inertness

Clean peak shape, even for basic, acidic, or metal-sensitive compounds.

Low Back Pressure

Low Back Pressure

Engineered silica design supports fast flow rates and high-throughput LC systems.

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Picture for category C18 Columns
C18 Columns
Picture for category C8 & C4 HPLC Columns
C8 & C4 HPLC Columns
Picture for category C30 HPLC Columns
C30 HPLC Columns
Picture for category PFP & Phenyl HPLC Columns
PFP & Phenyl HPLC Columns
Picture for category Cyano HPLC Columns
Cyano HPLC Columns
Picture for category HILIC HPLC Columns
HILIC HPLC Columns
Picture for category Normal Phase HPLC Columns
Normal Phase HPLC Columns
Picture for category SEC HPLC Columns
SEC HPLC Columns
Picture for category Ion Exchange HPLC Columns
Ion Exchange HPLC Columns
Picture for category Monolithic HPLC Columns
Monolithic HPLC Columns
Picture for category Bioseparation LC columns
Bioseparation LC columns
Picture for category Application Specific Columns
Application Specific Columns
Picture for category HPLC Guard Columns
HPLC Guard Columns
Picture for category HPLC Column Equivalents
HPLC Column Equivalents
Featured Products
Get the Right Column for Your Compound
InertSustain C18 First choice for ultra-high inertness and high durability, delivering superior peak shapes with low back pressure.
Inertsil ODS-3 Most popular C18, trusted for long-established methods, offering strong retentivity and high loading capacity.
InertSustain AQ-C18 First choice for high-polarity compounds, delivering strong retention even under 100% aqueous mobile phases.
Inertsil ODS-3V Validated version of ODS-3, designed for GLP/GMP compliance, ensuring batch-to-batch consistency.
InertSustainSwift C18 Ultra-inert, fast-separation C18 for high-throughput LC-MS and LC-MS/MS with superior peak symmetry.
InertSustain AX-C18 Mixed-mode C18 with anion exchange for strong retention of highly polar acidic compounds without ion-pairing.
InertSustain C8 Ultra-inert C8 column for rapid analysis of hydrophobic compounds with symmetric peaks across a wide pH range.
Inertsil C8 Ultra-pure silica C8 column for rapid analysis of hydrophobic compounds, ideal for legacy methods.
InertSustainSwift C8 Ultra-inert C8 column for low-polarity analytes, peptides, and oligonucleotides with optimized 200Å pore size.
Inertsil C8-3 Strong retentivity, very inert, and low back pressure, based on the same silica and bonding as Inertsil ODS-3.
Inertsil WP 300 Wide-pore C8 column for rapid, high-resolution separation of proteins and peptides with sharper peaks.
Inertsil C4 Low-retentivity C4 column for rapid analysis of highly hydrophobic compounds like fat-soluble vitamins.
InertSustain Amide First choice for HILIC mode, offering the strongest retention of polar compounds with superior stability in water-rich conditions.
Inertsil HILIC Diol-bonded HILIC column for excellent peak shape and strong retention of highly polar basic compounds.
InertSustain NH2 First choice for sugar analysis, offering superior stability, reproducibility, and compatibility with weakly acidic eluents.
Inertsil NH2 Aminopropyl column for sugar analysis, highly retentive in normal phase with superior stability and reproducibility.
ProteoSil HILIC Bioseparation-focused HILIC column, excelling in hydrophilic compound, peptide, glycan, and oligonucleotide analysis.
InertSustain PFP A pentafluorophenyl-modified column designed for enhanced separation of structurally similar compounds through multiple retention mechanisms, including π-π, dipole, and hydrogen bonding interactions.
InertSustain Phenyl A directly bonded phenyl group gives the InertSustain Phenyl column unique reversed-phase selectivity, ideal for separating polar compounds and structural isomers via π-π and hydrogen bonding interactions.
InertSustain Phenylhexyl A phenylhexyl-bonded column that offers complementary selectivity to traditional alkyl-chain columns, providing high inertness, reproducibility, and low back pressure.
InertSep C18 Silica sorbent with high end-capping, ideal for lipid removal & pesticide residue analysis.
InertSep C18-ENV C18 sorbent with low end-capping, optimized for water analysis & anionic surfactant removal.
InertSep HLB Versatile SPE column for extracting non-polar to highly polar compounds, with a wide pH range (1-14).
InertSep C8 Silica sorbent with octyl groups, offering weaker retention than C18 for highly retained compounds.
InertSep SCX Silica-based SPE column with strong cation exchange and non-polar interactions for enhanced retention.
InertSep SAX Monofunctional C18 sorbent with medium end-capping, allowing secondary interactions for versatile use.
MonoSpin C18 High-permeability spin column for peptide desalting, drug extraction, and fast biological sample preparation.
MonoSpin ProA Fast Protein A spin column for high-purity IgG antibody purification with >90% recovery.
MonoSpin C18-CX Mixed-mode spin column with C18 and cation exchange for enhanced basic drug recovery.
MonoSpin Phospholipid TiO₂/ZrO₂-coated spin column for efficient phospholipid removal and matrix effect reduction.
MonoSpin SAX Strong anion exchange spin column for fast extraction of acidic drugs with high recovery.
MonoSpin TiO TiO₂ spin column for phospholipid removal and organophosphorus pesticide purification.
InertSep QuEChERS Kit High-purity extraction and cleanup kit for pesticide residue analysis in food and environmental samples.
InertCap 1MS General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
InertCap 1 General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
InertCap 5MS/Sil General purpose, Halogenated compounds, Phenols, Pesticides, FAME
InertCap 5MS/NP General purpose, Halogenated compounds, Phenols, Pesticides, FAME
InertCap 5 General purpose, Halogenated compounds, Phenols, Pesticides, FAME
InertCap 624MS Residual solvents of Pharmaceuticals, VOCs, Alcohols

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