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HPLC Columns
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- C18 Columns
- C8 & C4 HPLC Columns
- HILIC HPLC Columns
- PFP & Phenyl HPLC Columns
- Bioseparation LC columns
- SEC HPLC Columns
- Ion Exchange HPLC Columns
- All HPLC Columns
- InertSustain C18 First choice for ultra-high inertness and high durability, delivering superior peak shapes with low back pressure.
- Inertsil ODS-3 Most popular C18, trusted for long-established methods, offering strong retentivity and high loading capacity.
- InertSustain AQ-C18 First choice for high-polarity compounds, delivering strong retention even under 100% aqueous mobile phases.
- Inertsil ODS-3V Validated version of ODS-3, designed for GLP/GMP compliance, ensuring batch-to-batch consistency.
- InertSustainSwift C18 Ultra-inert, fast-separation C18 for high-throughput LC-MS and LC-MS/MS with superior peak symmetry.
- InertSustain AX-C18 Mixed-mode C18 with anion exchange for strong retention of highly polar acidic compounds without ion-pairing.
- All C18 Columns visible-xs
- InertSustain C8 Ultra-inert C8 column for rapid analysis of hydrophobic compounds with symmetric peaks across a wide pH range.
- Inertsil C8 Ultra-pure silica C8 column for rapid analysis of hydrophobic compounds, ideal for legacy methods.
- InertSustainSwift C8 Ultra-inert C8 column for low-polarity analytes, peptides, and oligonucleotides with optimized 200Å pore size.
- Inertsil C8-3 Strong retentivity, very inert, and low back pressure, based on the same silica and bonding as Inertsil ODS-3.
- Inertsil WP 300 Wide-pore C8 column for rapid, high-resolution separation of proteins and peptides with sharper peaks.
- Inertsil C4 Low-retentivity C4 column for rapid analysis of highly hydrophobic compounds like fat-soluble vitamins.
- All C8 & C4 Columns visible-xs
- InertSustain Amide First choice for HILIC mode, offering the strongest retention of polar compounds with superior stability in water-rich conditions.
- Inertsil HILIC Diol-bonded HILIC column for excellent peak shape and strong retention of highly polar basic compounds.
- InertSustain NH2 First choice for sugar analysis, offering superior stability, reproducibility, and compatibility with weakly acidic eluents.
- Inertsil NH2 Aminopropyl column for sugar analysis, highly retentive in normal phase with superior stability and reproducibility.
- ProteoSil HILIC Bioseparation-focused HILIC column, excelling in hydrophilic compound, peptide, glycan, and oligonucleotide analysis.
- All HILIC Columns visible-xs
- InertSustain PFP A pentafluorophenyl-modified column designed for enhanced separation of structurally similar compounds through multiple retention mechanisms, including π-π, dipole, and hydrogen bonding interactions.
- InertSustain Phenyl A directly bonded phenyl group gives the InertSustain Phenyl column unique reversed-phase selectivity, ideal for separating polar compounds and structural isomers via π-π and hydrogen bonding interactions.
- InertSustain Phenylhexyl A phenylhexyl-bonded column that offers complementary selectivity to traditional alkyl-chain columns, providing high inertness, reproducibility, and low back pressure.
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Sample Preparation
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- SPE Cartridges & Columns
- Spin Columns
- Proteomics Products
- InertSep QuEChERS kit
- Cleanup/Separating Bulks
- SPE Manifolds
- ALL Sample Preparation
- InertSep C18 Silica sorbent with high end-capping, ideal for lipid removal & pesticide residue analysis.
- InertSep C18-ENV C18 sorbent with low end-capping, optimized for water analysis & anionic surfactant removal.
- InertSep HLB Versatile SPE column for extracting non-polar to highly polar compounds, with a wide pH range (1-14).
- InertSep C8 Silica sorbent with octyl groups, offering weaker retention than C18 for highly retained compounds.
- InertSep SCX Silica-based SPE column with strong cation exchange and non-polar interactions for enhanced retention.
- InertSep SAX Monofunctional C18 sorbent with medium end-capping, allowing secondary interactions for versatile use.
- All SPE Cartridges & Columns visible-xs
- MonoSpin C18 High-permeability spin column for peptide desalting, drug extraction, and fast biological sample preparation.
- MonoSpin ProA Fast Protein A spin column for high-purity IgG antibody purification with >90% recovery.
- MonoSpin C18-CX Mixed-mode spin column with C18 and cation exchange for enhanced basic drug recovery.
- MonoSpin Phospholipid TiO₂/ZrO₂-coated spin column for efficient phospholipid removal and matrix effect reduction.
- MonoSpin SAX Strong anion exchange spin column for fast extraction of acidic drugs with high recovery.
- MonoSpin TiO TiO₂ spin column for phospholipid removal and organophosphorus pesticide purification.
- All Spin Columns visible-xs
- Exosome Purification
- Desalting
- Digestion
- Fractionation
- Phosphopeptide Enrichment
- Centrifuge Accessories
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InertSep QuEChERS Kit High-purity extraction and cleanup kit for pesticide residue analysis in food and environmental samples.
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GC Columns
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- InertCap Series
- TC Series
- GC Accesories
- All GC Columns
- InertCap 1MS General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
- InertCap 1 General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
- InertCap 5MS/Sil General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 5MS/NP General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 5 General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 624MS Residual solvents of Pharmaceuticals, VOCs, Alcohols
- All GC Columns visible-xs
Get the Right Column for Your Compound — InstantlyWhat compound are you analyzing?QUICK LINKS- Application Search
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Instruments
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LD249 Gas Leak Detector Compact, easy-to-use leak detector with thermal conductivity sensor for fast, accurate gas detection. Replaces the LD239. -
FM4: Air Sampler for PFAS Low-volume air sampler for PFAS enabling comprehensive analysis of both gas and particle phases in a single sampling using stage-optimized materials. -
Intelligent Pump UI-22 Series Low-pulsation linear motor pump with precise flow control and bubble-free operation. -
OralChroma Halitosis Measuring Device High-precision breath analyzer using gas chromatography to quantify VSCs in 4 minutes — fast, reliable, and maintenance-free.
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LD249 Gas Leak Detector Latest model replacing LD239, with thermal conductivity detection for helium, hydrogen, and other gases.
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GF1010 Digital Gas Flowmeter Portable, volumetric meter for accurate GC gas flow measurement without gas selection.
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Intelligent Pump UI-22 Series Low-pulsation linear motor pump with precise flow control and bubble-free operation.
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Dual Pump KP-21 Series High-precision, medium to high-pressure pump with RS-232C control and customizable seals. -
Auto BPR BP-11 Auto Back Pressure Regulator for the UI-22 Series, maintaining stable pressure for consistent flow. -
PCS Pump SP-22 Series Single plunger pump with a pressure sensor, pulse control, and real-time pressure display for precise monitoring. -
Dual Pump KP-22 Series High-precision, low-pulsation pump with pulse control, real-time pressure display, and RS-232C control. -
PCS Pump SP-21 Series Cost-effective single plunger pump with pulse control, ideal for basic solvent dispensing. - All HPLC Pumps visible-xs
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Gastorr AG Series Reliable, CPU-controlled degassing system for low-flow applications with independent chamber design. -
Gastorr BG Series High-performance degassing system with real-time vacuum display and independent chamber design. -
Gastorr FG-42 Solvent degassing system optimized for fluorinated solvents with real-time vacuum display. -
Gastorr PG Series High-flow degassing system for fractionating applications with real-time vacuum display. - All Degassing Units visible-xs
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Accessories
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- HPLC Accesories
- SPE Accessories
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- Micro Splitter Valve
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Applications & Industries
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- Featured
- PFAS Solutions Products and workflows for EPA and ISO-compliant PFAS testing in water, air, and soil.
- Flow Chemistry Solutions Integrated pumps and pressure regulators for continuous, high-temperature flow chemistry reactions.
- Life Science/Bio Products Spin columns and purification tools for antibody capture, protein cleanup, and bioseparation workflows.
- Gas/Air Sampling Equipment Sampling tools for capturing VOCs, aldehydes, and trace gases in environmental and industrial settings.
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- HPLC Columns
- Sample Preparation
- GC Columns
-
Instruments
-
LD249 Gas Leak Detector Compact, easy-to-use leak detector with thermal conductivity sensor for fast, accurate gas detection. Replaces the LD239.
-
FM4: Air Sampler for PFAS Low-volume air sampler for PFAS enabling comprehensive analysis of both gas and particle phases in a single sampling using stage-optimized materials.
-
Intelligent Pump UI-22 Series Low-pulsation linear motor pump with precise flow control and bubble-free operation.
-
OralChroma Halitosis Measuring Device High-precision breath analyzer using gas chromatography to quantify VSCs in 4 minutes — fast, reliable, and maintenance-free.
-
- Accessories
- Applications & Industries
- Resources
- About
- Contact Us
C8 & C4 HPLC Columns
GL Sciences C8 and C4 columns are engineered to deliver clean peak shape, high inertness, and reproducible results — even for hydrophobic analytes and large biomolecules. Built with ultra-pure silica and advanced end-capping technology, InertSustain and ProteoSil phases reduce secondary interactions and ensure consistent performance across peptide, protein, and fat-soluble vitamin workflows. Available in 100–300 Å pore sizes, ideal for both small-molecule and wide-pore applications.
Compare
Product DetailsName⬍
Price⬍
InertSustain C8 is an octyl group (C8) bonded column delivering the same extreme inertness to any type of compounds just like InertSustain C18, which enables rapid analysis of highly hydrophobic compounds delivering symmetric peaks at a wide range of pH.
InertSustainSwift C8 is an octyl group (C8) bonded column offering the same extreme inertness to any type of compounds just like InertSustainSwift C18, which is ideal for analyzing low polarity analytes. In addition, the optimized 200Å pore size silica enables to analyze and retain peptides and oligonucleotides which have a molecular weight from several kDa to several dozen ...
Many chromatographers prefer a C8 column when an ODS phase shows excessive retention values. Inertsil C8-4 provides the same separation pattern (selectivity) and extreme inertness to any type of compounds just like Inertsil ODS-4, which enables easy method transfer from ODS-4 to C8-4 while other commercially available ODS and C8 columns can show dramatically different ...
The same base silica gel and bonding technology that is used for Inertsil ODS-3 is also employed for Inertsil C8-3. The difference between the two phases is just the length of the hydrocarbon ligands. 10 μm particle size columns are also available to meet the requirement of various pharmacopeia methods. We recommend InertSustain C8 columns for all new method development.
Specialized for the analysis of mid-sized molecules, the ProteoSil 200-C8 shows superior retention for analytes that are strongly retained by C18 columns
Optimized for proteins and peptides, the ProteoSil 300-C8 ensures unique selectivity and hydrophobicity compared to shorter-chain C4 phases, suitable for protein and hydrophobic peptide separations.
Inertsil C8 columns have a pore size of 150 Å and it is recommended for rapid analysis of highly hydrophobic compounds. We recommend InertSustain C8 or Inertsil C8-4 columns for all new method development.
Inertsil C4 columns have a pore size of 150 Å and is recommended for rapid analysis of highly hydrophobic compounds such as fat-soluble vitamins.
Inertsil WP300 C8 (wide pore size of 300 Å) columns bring the same legendary performance of Inertsil's narrow-pore HPLC products to columns designed specifically for the reproducible rapid separations of proteins and peptides. Inertsil WP300 C8 delivers rapid analysis with sharper peaks compared to Inertsil WP300 C18.
Tailored for the analysis of proteins and peptides, especially hydrophobic peptides, the ProteoSil 300-C4 facilitates shorter retention times and is ideal for proteins with moderate retention needs.
Inertsil WP300 C4 is a butyl group bonded phase utilizing silica gel with wide pores (300 Å). Also, an optimal polar group is embedded between silica surface and butyl group, which reduces adsorption of basic compounds and fat-soluble proteins. Inertsil WP300 C4 is recommended for the analysis of large, highly fat-soluble proteins and peptides.
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5 µm
300 Å (30 nm)
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$994.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$1,078.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$869.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$2,165.00 / 1 pc.
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5 µm
300 Å (30 nm)
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-
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$1,099.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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-
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$1,078.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$869.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$1,893.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$1,893.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$889.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$1,099.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$1,318.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$994.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$1,318.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$994.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$994.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$1,245.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$1,078.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$1,140.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$2,165.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$1,820.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$1,935.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$1,099.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$994.00 / 1 pc.
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5 µm
300 Å (30 nm)
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-
-
$889.00 / 1 pc.
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5 µm
300 Å (30 nm)
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-
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$994.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$994.00 / 1 pc.
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3 µm HP
200 Å (20 nm)
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$1,140.00 / 1 pc.
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3 µm
200 Å (20 nm)
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$1,820.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$994.00 / 1 pc.
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5 µm
300 Å (30 nm)
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$1,099.00 / 1 pc.
L7
3 µm HP
200 Å (20 nm)
200 m2/g
6.0%
Yes
$805.00 / 1 pc.
L7
5 µm
150 Å (15 nm)
320 m2/g
10.5%
Yes
$1,538.00 / 1 pc.
L7
5 µm
100 Å (10 nm)
450 m2/g
5.0%
Yes
$712.00 / 1 pc.
L7
5 µm
200 Å (20 nm)
200 m2/g
6.0%
Yes
$920.00 / 1 pc.
L26
5 µm
150 Å (15 nm)
320 m2/g
7.5%
Yes
$1,172.00 / 1 pc.
L7
3.5 µm
100 Å (10 nm)
450 m2/g
9.0%
Yes
$920.00 / 1 pc.
L7
10 µm
100 Å (10 nm)
450 m2/g
9.0%
Yes
$2,144.00 / 1 pc.
L7
5 µm
150 Å (15 nm)
320 m2/g
10.5%
Yes
$597.00 / 1 pc.