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GL Sciences HPLC Columns

The most trusted HPLC columns since 1968.  Our wide range of phases offer reliable equivalent columns for Agilent Zorbax HPLC columns.

High Inertness
Low Back Pressure
High Reproducibility

Product Reviews


“The (InertSustain) columns showed very good stability & reproducibility of the separation when utilized for a period of about six month with hundreds of injections.  The columns are stable in a wide range of pH & perfectly suitable for separations followed by MS detection. “

Dr. Serban Moldoveanu, RJ Reynolds Tobacco Co.


"I was using the corresponding InertSustain (column) and was pleased with the results.  The column looks to have a much longer lifetime."

David Budac, Ph.D, Principal Scientist, PsychoGenics


“I was very impressed by the performance of the InertSustain C18 column. Thank you again for suggesting it and sending us one to try!”

Anthony R. Horner, Ph.D,  Research Chemist, PPG


Discover The Advantages of GL Sciences' InertSustain HPLC Columns

GL Sciences next generation HPLC Columns, InertSustain employ a radically new type of silica, in which the surface of the silica is uniquely modified, enabling precise control of the silica properties.  

InertSustain inherits the advantages of all the current Inertsil HPLC columns (e.g., extremely low operating back pressure, superior inertness to typically any analytes, high efficiency & compatibility with a wide range of solvents), and now can be used for wide pH analysis with consistent performance from column-to-column and lot-to-lot.

InertSustain HPLC Columns Deliver:



InertSustain employs a radically new type of silica, in which the surface of the silica is uniquely modified, enabling precise control of the silica properties and adsorption sites and silanol distribution are strictly controlled.

Unmatched Inertness & Durability

1st Stage
[Synthesis of “Evolved Surface Silica”]
As the adsorption sites and silanol distribution are strictly controlled from the synthesis procedure of the Evolved Surface Silica, InertSustain delivers unmatched inertness to virtually any type of analyte with high durability to acidic, basic mobile phase conditions.
2nd Stage
[Chemical Bonding of ODS group]
The introduction of Evolved Surface Silica and our cutting-edge chemical bonding technology make InertSustain compatible with 100 % aqueous mobile phases, while maintaining strong non-polar retentivity.
3rd Stage
[Complete End-capping]
GL Sciences’ complete end-capping technology allows InertSustain to provide high efficiency and superior peak shape even to those well-known strong adsorptive analytes.

Excellent Peak Resolution

Get clear separation with excellent pick shape for all types of analytes using InertSustain.

Basic Compound

Acidic Compound

Chelating Compound

Reliable Reproducibility

High inertness also provides consistent results through multiple runs and InertSustain's envolved surface silica production method allows for reproducibility across different particle sizes.

Wide pH Compatibility

InertSustain provides higher pH stability compare to competitors. Good end-capping enables high theoretical plates to be maintained even after extended exposure to extreme pH conditions. With InertSustain, analysis results are not affected by sample or mobile phase conditions.

Extremely Low Operating Back Pressure

InertSustain provides excellent column lifetime thanks to having low operating back pressure. Precise manufacturing of silica particles allows for uniform particle with equal distribution and dimension providing superior flow. The extreme low back pressure of InertSustain columns ensure long service life leading to less running costs.

Batch to Batch Reproducibility

InertSustain is delivered with consistent lot performance thanks to GL Sciences' state-of-the-art column manufacturing technology.

Equivalent Columns For Agilent Zorbax HPLC Columns

C18 Columns

GL Sciences C18 ColumnsComparable Column
InertSustain C18

Zorbax Extend C18

Pursuit XRS C18

Inertsil ODS-3Zorbax ODS
Inertsil ODS-4Zorbax Eclipse XDB-C18
Zorbax Eclipse AAA
Inertsil ODS-P

Zorbax Eclipse PAH
Zorbax Rx-C18 
Zorbax StableBond SB-C18 

Inertsil WP300 C18Zorbax 300 Extend-C18
Zorbax StableBond 300SB-C18
Zorbax 300 Extend-C18

Inertsil ODS-HLPrep C18

Other HPLC Columns

GL Sciences ColumnsComparable ColumnBonding Type
InertSustain C8Zorbax StableBond 300SB-C8
Zorbax Eclipse Plus C8
Zorbax Eclipse XDB-C8
Zorbax Rx-C8
Zorbax StableBond SB-C8
Pursuit XRS C8
InertSustainSwift C8Pursuit XRS Ultra 2.8 C8C8
InertSustain Phenyl

Zorbax StableBond SB-Phenyl
Zorbax Eclipse XDB-Phenyl

InertSustain PhenylhexylZorbax Eclipse Plus Phenyl-HexylPhenyl-Hexyl
InertSustain CyanoZorbax Eclipse XDB-CN
Zorbax CN
Inertsil CN-3Zorbax SB-300SB-CN
Zorbax StableBond SB-CN
Inertsil DiolZorbax GF-250Diol
Inertsil WP300 DiolZorbax GF-450Diol
Inertsil SIL-100AZorbax SILSilica
Inertsil SIL-150AZorbax Rx-SILSilica
Inertsil WP300 SILZorbax HILIC PlusSilica



There are application notes for GL Sciences HPLC Columns.
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