Inertsil Diol has characteristics of dihydroxypropyl group bonded phase. It shows unique selectivity normal phase mode. The separation mechanism of diol column is featured by hydrogen bonding interactions between diol groups and polar compounds. Diol columns provide an alternative selectivity to silica columns often with increased retentivity.
Figure 1, selectivities of Inertsil Diol and Inertsil SIL-100A(a pure Silica gel column) are compared. Inertsil Diol shows higher selectivity for those compounds.
Figure 2, 9 compounds are eluted by Inertsil Diol and other normal phase columns of “Inertsil series”. By comparing their retention times of each compound, it is noticeable that Inertsil Diol provides stable retention for all of the compounds, including basic and acidic compounds. As nonspecific adsorption of water is reduced, Inertsil Diol can be washed by 100 % water eluent.