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HPLC Columns
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- C18 Columns
- C8 & C4 HPLC Columns
- HILIC HPLC Columns
- PFP & Phenyl HPLC Columns
- Bioseparation LC columns
- SEC HPLC Columns
- Ion Exchange HPLC Columns
- All HPLC Columns
- InertSustain C18 First choice for ultra-high inertness and high durability, delivering superior peak shapes with low back pressure.
- Inertsil ODS-3 Most popular C18, trusted for long-established methods, offering strong retentivity and high loading capacity.
- InertSustain AQ-C18 First choice for high-polarity compounds, delivering strong retention even under 100% aqueous mobile phases.
- Inertsil ODS-3V Validated version of ODS-3, designed for GLP/GMP compliance, ensuring batch-to-batch consistency.
- InertSustainSwift C18 Ultra-inert, fast-separation C18 for high-throughput LC-MS and LC-MS/MS with superior peak symmetry.
- InertSustain AX-C18 Mixed-mode C18 with anion exchange for strong retention of highly polar acidic compounds without ion-pairing.
- All C18 Columns visible-xs
- InertSustain C8 Ultra-inert C8 column for rapid analysis of hydrophobic compounds with symmetric peaks across a wide pH range.
- Inertsil C8 Ultra-pure silica C8 column for rapid analysis of hydrophobic compounds, ideal for legacy methods.
- InertSustainSwift C8 Ultra-inert C8 column for low-polarity analytes, peptides, and oligonucleotides with optimized 200Å pore size.
- Inertsil C8-3 Strong retentivity, very inert, and low back pressure, based on the same silica and bonding as Inertsil ODS-3.
- Inertsil WP 300 Wide-pore C8 column for rapid, high-resolution separation of proteins and peptides with sharper peaks.
- Inertsil C4 Low-retentivity C4 column for rapid analysis of highly hydrophobic compounds like fat-soluble vitamins.
- All C8 & C4 Columns visible-xs
- InertSustain Amide First choice for HILIC mode, offering the strongest retention of polar compounds with superior stability in water-rich conditions.
- Inertsil HILIC Diol-bonded HILIC column for excellent peak shape and strong retention of highly polar basic compounds.
- InertSustain NH2 First choice for sugar analysis, offering superior stability, reproducibility, and compatibility with weakly acidic eluents.
- Inertsil NH2 Aminopropyl column for sugar analysis, highly retentive in normal phase with superior stability and reproducibility.
- ProteoSil HILIC Bioseparation-focused HILIC column, excelling in hydrophilic compound, peptide, glycan, and oligonucleotide analysis.
- All HILIC Columns visible-xs
- InertSustain PFP A pentafluorophenyl-modified column designed for enhanced separation of structurally similar compounds through multiple retention mechanisms, including π-π, dipole, and hydrogen bonding interactions.
- InertSustain Phenyl A directly bonded phenyl group gives the InertSustain Phenyl column unique reversed-phase selectivity, ideal for separating polar compounds and structural isomers via π-π and hydrogen bonding interactions.
- InertSustain Phenylhexyl A phenylhexyl-bonded column that offers complementary selectivity to traditional alkyl-chain columns, providing high inertness, reproducibility, and low back pressure.
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Sample Preparation
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- SPE Cartridges & Columns
- Spin Columns
- Proteomics Products
- InertSep QuEChERS kit
- Cleanup/Separating Bulks
- SPE Manifolds
- ALL Sample Preparation
- InertSep C18 Silica sorbent with high end-capping, ideal for lipid removal & pesticide residue analysis.
- InertSep C18-ENV C18 sorbent with low end-capping, optimized for water analysis & anionic surfactant removal.
- InertSep HLB Versatile SPE column for extracting non-polar to highly polar compounds, with a wide pH range (1-14).
- InertSep C8 Silica sorbent with octyl groups, offering weaker retention than C18 for highly retained compounds.
- InertSep SCX Silica-based SPE column with strong cation exchange and non-polar interactions for enhanced retention.
- InertSep SAX Monofunctional C18 sorbent with medium end-capping, allowing secondary interactions for versatile use.
- All SPE Cartridges & Columns visible-xs
- MonoSpin C18 High-permeability spin column for peptide desalting, drug extraction, and fast biological sample preparation.
- MonoSpin ProA Fast Protein A spin column for high-purity IgG antibody purification with >90% recovery.
- MonoSpin C18-CX Mixed-mode spin column with C18 and cation exchange for enhanced basic drug recovery.
- MonoSpin Phospholipid TiO₂/ZrO₂-coated spin column for efficient phospholipid removal and matrix effect reduction.
- MonoSpin SAX Strong anion exchange spin column for fast extraction of acidic drugs with high recovery.
- MonoSpin TiO TiO₂ spin column for phospholipid removal and organophosphorus pesticide purification.
- All Spin Columns visible-xs
- Exosome Purification
- Desalting
- Digestion
- Fractionation
- Phosphopeptide Enrichment
- Centrifuge Accessories
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InertSep QuEChERS Kit High-purity extraction and cleanup kit for pesticide residue analysis in food and environmental samples.
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GC Columns
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- InertCap Series
- TC Series
- GC Accesories
- All GC Columns
- InertCap 1MS General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
- InertCap 1 General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
- InertCap 5MS/Sil General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 5MS/NP General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 5 General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 624MS Residual solvents of Pharmaceuticals, VOCs, Alcohols
- All GC Columns visible-xs
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Instruments
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LD249 Gas Leak Detector Compact, easy-to-use leak detector with thermal conductivity sensor for fast, accurate gas detection. Replaces the LD239. -
FM4: Air Sampler for PFAS Low-volume air sampler for PFAS enabling comprehensive analysis of both gas and particle phases in a single sampling using stage-optimized materials. -
Intelligent Pump UI-22 Series Low-pulsation linear motor pump with precise flow control and bubble-free operation. -
OralChroma Halitosis Measuring Device High-precision breath analyzer using gas chromatography to quantify VSCs in 4 minutes — fast, reliable, and maintenance-free.
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LD249 Gas Leak Detector Latest model replacing LD239, with thermal conductivity detection for helium, hydrogen, and other gases.
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GF1010 Digital Gas Flowmeter Portable, volumetric meter for accurate GC gas flow measurement without gas selection.
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Intelligent Pump UI-22 Series Low-pulsation linear motor pump with precise flow control and bubble-free operation.
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Dual Pump KP-21 Series High-precision, medium to high-pressure pump with RS-232C control and customizable seals. -
Auto BPR BP-11 Auto Back Pressure Regulator for the UI-22 Series, maintaining stable pressure for consistent flow. -
PCS Pump SP-22 Series Single plunger pump with a pressure sensor, pulse control, and real-time pressure display for precise monitoring. -
Dual Pump KP-22 Series High-precision, low-pulsation pump with pulse control, real-time pressure display, and RS-232C control. -
PCS Pump SP-21 Series Cost-effective single plunger pump with pulse control, ideal for basic solvent dispensing. - All HPLC Pumps visible-xs
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Gastorr AG Series Reliable, CPU-controlled degassing system for low-flow applications with independent chamber design. -
Gastorr BG Series High-performance degassing system with real-time vacuum display and independent chamber design. -
Gastorr FG-42 Solvent degassing system optimized for fluorinated solvents with real-time vacuum display. -
Gastorr PG Series High-flow degassing system for fractionating applications with real-time vacuum display. - All Degassing Units visible-xs
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Accessories
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- HPLC Accesories
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Applications & Industries
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- Featured
- PFAS Solutions Products and workflows for EPA and ISO-compliant PFAS testing in water, air, and soil.
- Flow Chemistry Solutions Integrated pumps and pressure regulators for continuous, high-temperature flow chemistry reactions.
- Life Science/Bio Products Spin columns and purification tools for antibody capture, protein cleanup, and bioseparation workflows.
- Gas/Air Sampling Equipment Sampling tools for capturing VOCs, aldehydes, and trace gases in environmental and industrial settings.
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- HPLC Columns
- Sample Preparation
- GC Columns
-
Instruments
-
LD249 Gas Leak Detector Compact, easy-to-use leak detector with thermal conductivity sensor for fast, accurate gas detection. Replaces the LD239.
-
FM4: Air Sampler for PFAS Low-volume air sampler for PFAS enabling comprehensive analysis of both gas and particle phases in a single sampling using stage-optimized materials.
-
Intelligent Pump UI-22 Series Low-pulsation linear motor pump with precise flow control and bubble-free operation.
-
OralChroma Halitosis Measuring Device High-precision breath analyzer using gas chromatography to quantify VSCs in 4 minutes — fast, reliable, and maintenance-free.
-
- Accessories
- Applications & Industries
- Resources
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C18 Columns
Reliable, Reproducible Separations for Regulated Workflows
Trusted in regulated labs worldwide, GL Sciences C18 columns deliver clean peak shape, high reproducibility, and proven performance across validated methods. Explore leading phases like InertSustain, Inertsil, and ProteoSil — engineered for diverse reversed-phase applications from pharmaceuticals to food safety.
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Product DetailsName⬍
Price⬍
Generally, silica based columns are mechanically stable and provide high efficiencies, however, they cannot be used under alkaline conditions and their residual silanol groups tend to adsorb organic bases. InertSustain C18 employs a radically new type of silica, in which the surface of the silica is uniquely modified, enabling precise control of the silica properties. ...
InertSustain AQ-C18 columns are designed to achieve strong retention for highly polar compounds, which is the most challenging goals in developing reversed phase methods. The optimization of bonding of the C18 groups at equal distance to the silica gel enable InertSustain AQ-C18 columns to offer significant retention for highly polar compounds even under water rich mobile ...
Increasing Efficiency, Throughput and Productivity
InertSustainSwift C18 columns are designed to deliver rapid separations with symmetric peaks to minimize analysis time as much as possible. InertSustainSwift C18 is also ideal for LC-MS and LC-MS/MS methods which offer highly sensitive results and enables MS compatible buffers to be used due to the extremely inert silica ...
InertSustain AX-C18 is a mix-mode column bonded with C18 groups and tertiary amino groups. It provides hydrophobic interaction and electrostatic interaction by Anion Exchange group works. By controlling the amount of Anion Exchange group, acidic compounds can be eluted even in the buffer concentration range used with LC/MS.
The High Performance Core-shell Column For UHPLC/HPLC
Ultra High Retentivity Ideal for Separation of Basic Molecules & its Related Substances, Process Impurities
Inertsil ODS-HL employs a highly inert packing material which provides pure hydrophobic interaction between analytes without generating any secondary interaction delivering sharp peaks. High-Density bonding of C18 phase delivers alternative selectivity to conventional ...
Inertsil ODS-4 delivers the same extreme inertness to any type of compounds just like InertSustain C18 along with unprecedented stability under 100 % aqueous mobile phases for qualitative and quantitative analysis. However, as the base silica gel and carbon loading are different on Inertsil ODS-4, differences in selectivity can be observed for certain analytes.
Inertsil ODS-3 is still GL Sciences’ most popular phase and continues to be used widely and reliably for long-established methods in pharmaceutical, and contract research labs. Inertsil ODS-3 columns have a relatively strong retentivity compared to commercially available ODS columns. In addition, the introduction of higher surface area silica provide high preparative loading ...
Inertsil ODS-4 columns have proven superior worldwide for analysis of strong pharmaceutical bases, acids, chelating compounds, and zwitterions. The long-awaited validated Inertsil ODS-4V has now been added to our product lineup.
Each Inertsil ODS-4V is delivered with a Manufacturer’s Validation Certificate showing the detailed results of every QA and QC step in manufacturing. ...
Inertsil ODS-3V offers all of the outstanding chromatographic benefits of Inertsil ODS-3 with the added benefit of a more thoroughly documented, validated QC procedure consistent with the demands of GLP/GMP compliance. Each Inertsil ODS-3V is delivered with a Manufacturer‘s Validation Certificate showing the detailed results of every QA and QC step in manufacturing.
The ...
Inertsil ODS-SP is super base deactivated and optimally bonded to retain hydrophilic compounds without excessive retention of hydrophobic compounds achieving better separations faster than before. As the carbon load of Inertsil ODS-SP is relatively low, it is compatible with 100 % aqueous eluents and offer faster equilibration of column for gradient analysis.
GL Sciences offers a polymerically bonded ODS-P phase which provide high steric selectivity for separation of planar and non-planar compounds. nertsil ODS-P columns are also ideal for the HPLC analysis of 16 PAH compounds, listed as target pollutants by the US EPA.
Inertsil ODS-EP contains a polar functional group embedded between the silica surface and the C18 group. The embedded polar group makes the C18 phase stable in 100 % aqueous eluents without "phase collapse."
This phase is also extremely "base deactivated" and provides superior peak shape for acids and bases in organic eluents as well as acidified eluents typically used in ...
Inertsil ODS-2 columns have a pore size of 150 Å offering symmetric peaks for bases, acids with low pressure. When Inertsil ODS-2 was introduced in 1987s, this HPLC transformed the entire industry. Inertsil ODS-2 was the first HPLC phase created using ultra high purity silica, which produced superior base deactivation. Inertsil ODS-2 is one of the most popular phase and ...
Inertsil ODS columns are general purpose, reversed phase C18 columns available in 5 μm and 10 μm particle sizes. It was the first ODS bonded phase introduced from GL Sciences back in 1986.
We recommend InertSustain C18 or Inertsil ODS-4 columns for all new method development.
Inertsil WP300 C18 (wide pore size of 300 Å) columns bring the same legendary performance of Inertsil's narrow-pore HPLC products to columns designed specifically for the reproducible separations of proteins and peptides. The results of GL Sciences’ original end-capping technique provide high efficiency and good peak shape for proteins and peptides.
The 200 Å pore size silica creates the opportunity to separate compounds having a molecular weight from small to large molecules. In addition, the usage of highly inert packing material packed into a new Steel-Coated-PEEK hardware deliver excellent peak shapes for various analytes without any adsorption.
Designed for advanced protein analysis, the ProteoSil 300-C18 column offers the ideal capabilities when enhanced retention and sample load are critical for C4 or C8 columns.
Ideal for mid-sized molecules, the ProteoSil 200-C18 column allows for separation across 100Å pore columns and is easy to clean for faster analysis.
Offering high inertness and durability, the ProteoSil 100-C18 is perfect for analyzing low-molecular-weight compounds, enhancing sensitivity in LC-MS applications.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,339.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,078.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,339.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,078.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,339.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,078.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,413.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,109.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,413.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,109.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,413.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,109.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,413.00 / 1 pc.
L1
3 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,109.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,088.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$942.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$942.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$869.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$869.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$1,088.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$942.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$942.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$869.00 / 1 pc.
L1
2 µm
100 Å (10 nm)
450 m2/g
15.0%
Yes
$869.00 / 1 pc.
L1
5 µm
100 Å (10 nm)
450 m2/g
11.0%
Yes
$3,880.00 / 1 pc.
L1
5 µm
100 Å (10 nm)
450 m2/g
11.0%
Yes
$3,430.00 / 1 pc.
L1
5 µm
100 Å (10 nm)
450 m2/g
11.0%
Yes
$2,980.00 / 1 pc.
L1
5 µm
100 Å (10 nm)
450 m2/g
11.0%
Yes
$1,800.00 / 1 pc.
L1
5 µm
100 Å (10 nm)
450 m2/g
11.0%
Yes
$3,200.00 / 1 pc.