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SPE Spin Centrifuge Columns

GL Sciences MonoSpin SPE spin columns provide improved concentration and yield for low-volume sample pre-treatment using centrifuge. MonoSpin features GL Sciences’ monolith silica technology with low-pressure, high-flow, and low-liquid-retention properties that allow for extraction with high recovery using smaller sample volumes compared to traditional particle media. MonoSpin columns are available in several formats for loading different sample volumes onto centrifuge. Read more

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Octadecyl functional group. Optimal for drug extraction in biological samples, and desalting & enrichment of peptide samples. For high viscosity samples, check out C18 FF which employs large through-pore monolith silica. Specifications Stationary phase: Octadecyl Through-pore: 5 µm (S-type) / 10 µm (L-type) / 20 µm (S-type FF) M...
From $192.00
Phenyl functional group. Optimal for the recovery of hydrophobic drugs in biological samples due to its weak retentivity and different selectivity compared to a C18 phase. Specifications Stationary phase: Phenyl Through-pore: 5 µm Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Amitriptyline) Available f...
From $214.00
Bounded with trimethylaminopropyl combining both strong anion exchange & weak hydrophobic interaction. Optimal for the extraction of acidic drugs. Specifications Stationary phase: Trimethylaminopropyl Through-pore: 5 µm (S-type) / 10 µm (L-type) Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Ibuprofen) ...
From $192.00
Bounded with benzenesulfonic acid combining both strong cation exchange & hydrophobic interaction. Optimal for the extraction of basic drugs. Specifications Stationary phase: Propylbenzenesulfonic acid Through-pore: 5 µm (S-type) / 10 µm (L-type) Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Amitriptyline...
From $192.00
Bounded with octadecyl and trimethylaminopropyl, a mix mode type. Delivers great retention for high salt concentrated serum samples. Optimal for the recovery of acidic drugs. Specifications Stationary phase: Octadecyl, Trimethylaminopropyl Through-pore: 5 µm Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (I...
From $214.00
Bounded with octadecyl and benzene sulfonic acid combining both ion exchange & hydrophobic interaction. Optimal for dissociated basic drug in biological samples. Delivers higher cleanup efficiency compound to C18 or SCX. Specifications Stationary phase: Octadecyl, Propylbenzenesulfonic acid Through-pore: 5 µm Mesopore: 10 nm Surfac...
From $214.00
Bounded with carboxyl acid combining both weak cation exchange. Optimal for the extraction of basic drugs. Specifications Stationary phase: Carboxyl Through-pore: 5 µm (S-type) / 10 µm (L-type) Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Amitriptyline) Available formats: S-type spin column, L-type la...
From $192.00
Monolith skeleton coated with titanium dioxide. Excellent for the adsorption and removal of phospholipids. Specifications Stationary phase: Titanium dioxide Through-pore: 20 µm Mesopore: 15 nm Surface area: 200 m2/g Sample loading capacity: 40 μg (Adenosine monophosphate) Available formats: S-type spin column
From $290.00
Bonded with iminodiacetic acid. Optimal for the recovery of trace metals. Specifications Stationary phase: Iminodiacetic acid Through-pore: 5 µm (S-type) / 10 µm (L-type) Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 25 µg (Cu ions) Available formats: S-type spin column, L-type large volume reservoir
From $242.00
Bounded with aminopropyl. Optimal for the enrichment of sugar chain and/or hydrophilic compounds by HILIC mode. Specifications Stationary phase: Aminopropyl Through-pore: 5 µm (S-type) / 10 µm (L-type) Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Maltopentaose) Available formats: S-type spin column, L...
From $192.00
Monolith skeleton coated with TiO2 and ZrO2. Excellent for the adsorption and removal of phospholipids. Specifications Stationary phase: Titanium dioxide, Zirconium dioxide Through-pore: 5 µm (S-type) / 10 µm (L-type) Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 10 μL (Human serum) Available formats: S-type s...
From $250.00
High selectivity columns with phenyl boronic acid. Optimal for selective extraction of cis diols, such as catecholamines. Specifications Stationary phase: Phenylboronic acid Through-pore: 5 µm Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Dopamine) Available formats: S-type spin column, 96-well plate
From $266.00
Bounded with amide. Optimal for the extraction of sugar chain chains and various hydrophilic acidic and basic compounds by HILIC mode. Specifications Stationary phase: Amide Through-pore: 5 µm Mesopore: 10 nm Surface area: 350 m2/g Sample loading capacity: 100 μg (Angiotensin II) Available formats: S-type spin column, 96-well p...
From $214.00
SKU# 5010-21725
$214.00
SKU# 5010-21700
$214.00
SKU# 5010-21701
$376.00
SKU# 5010-21705
$290.00
SKU# 5010-21706
$512.00
SKU# 5010-21710
$214.00
SKU# 5010-21711
$376.00
SKU# 5010-21715
$266.00
SKU# 5010-21716
$484.00
SKU# 5010-21720
$214.00
SKU# 5010-21726
$376.00
SKU# 5010-21727
$214.00
SKU# 5010-21728
$376.00
SKU# 5010-21729
$214.00
SKU# 5010-21730
$376.00
SKU# 5010-21731
$214.00
SKU# 5010-21732
$376.00
SKU# 7510-11320
$192.00
SKU# 7510-11321
$192.00
SKU# 7510-11322
$192.00
SKU# 7510-11323
$192.00
SKU# 7510-11324
$192.00
SKU# 7510-11325
$250.00
SKU# 7510-11326
$250.00
SKU# 5010-21670
$214.00
SKU# 5010-21671
$376.00
SKU# 5010-21721
$376.00
SKU# 5010-21733
$214.00
SKU# 5010-21734
$376.00
SKU# 5010-21735
$214.00
SKU# 5010-21736
$376.00
SKU# 5010-21737
$242.00
SKU# 5010-21738
$433.00
SKU# 5010-21699
$467.00
SKU# 5010-21900
$400.00
SKU# 5010-21901
$400.00

Available Formats for Spin Columns​

MonoSpin columns are available in the following formats:

 

S Type spin column

L Type large volume reservoir spin column

96-well plate

  • Disk size: 4.2 O.D. x 1.5 mm
  • Sample volume: 50-800 µL
  • Elution volume: 50-800 µL
  • Centrifugation speed: 2,000-10,000 x g
  • Disk size: 9 O.D. × 3 mm
  • Sample volume: 0.5-8 mL
  • Elution volume: 0.5-8 mL
  • Centrifugation speed: 1,000 x g
  • Disk size: 4.2 O.D × 1.5 mm
  • Sample volume:~800 µL
  • Elution volume: 100-800 µL
  • Centrifugation speed: 2,000-10,000 x g (centrifuge; can also be used in vacuum aspiration)
 

Available Functional Groups for Spin Columns​

 

How to choose Functional Groups

The MonoSpin series are optimized as a spin-column for pretreatment of biological samples. If you are working on highly viscous samples such as blood, MonoSpin C18 FF is the best choice. Please refer to the following chart for choosing appropriate MonoSpin:

Choosing functional groups for MonoSpin by sample viscosity
 

MonoSpin Features

  • Easy operation by centrifuge
  • Speedy sample treatment with a superb through pore
  • Excellent reproducibility (S-type) even at elution volumes of 100 μL or less
MonoSpin columns
 

Silica Monolith packing material

New separation media that are neither particulate nor membrane

Silica monoliths are integral silica gels with uniform continuous pores synthesized from ethyl silicate. They have high liquid permeability and large surface area possessing a structure with through-pores and mesopores on the framework surface. This state-of-the-art media is becoming popular globally for its characteristics: high recovery and high performance of adsorption and desorption. 

MonoSpin silica monolith structure
 

Advantages to conventional particle type packing

  • Disk-shaped silica monoliths do not use frits to hold particle media
  • The massive surface area of monolithic material makes it possible makes it possible to retain samples in the cartridge and completely elute small samples during processing allowing for much smaller volumes of sample needed.
  • Despite high liquid permeability, silica monoliths are still suitable for rapid elution without the loss of high recovery with fast sample diffusion and quick separation.
Silica monolith packing
 
Particle packing
 
 

How to Operate

 
 

Steps in Centrifugation for Spin Columns

Steps in using Spin Columns with Centrifuge

Whole process for sample treatment can be done within 10 minutes. 

 

Performance in analysis of trace analytes

Due to its high permeability, MonoSpin series enables collection of trace analytes without the need for dilution.

 

S type Column

MonoSpin S Type Column Performance in analysis of Trace samples
 

L Type Column

MonoSpin L Type Column Performance in analysis of Trace samples
 

Spin Columns Resources:​

  • Download GL Sciences MonoSpin SPE Spin Columns Catalog — Latest Spin Column Technology Download
  • Download our entire 2022 Consumables Catalog — Download
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