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- C18 Columns
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- InertSustain C18 First choice for ultra-high inertness and high durability, delivering superior peak shapes with low back pressure.
- Inertsil ODS-3 Most popular C18, trusted for long-established methods, offering strong retentivity and high loading capacity.
- InertSustain AQ-C18 First choice for high-polarity compounds, delivering strong retention even under 100% aqueous mobile phases.
- Inertsil ODS-3V Validated version of ODS-3, designed for GLP/GMP compliance, ensuring batch-to-batch consistency.
- InertSustainSwift C18 Ultra-inert, fast-separation C18 for high-throughput LC-MS and LC-MS/MS with superior peak symmetry.
- InertSustain AX-C18 Mixed-mode C18 with anion exchange for strong retention of highly polar acidic compounds without ion-pairing.
- All C18 Columns visible-xs
- InertCore Biphenyl Core-shell biphenyl for UHPLC/HPLC with superior π-π selectivity and strong retention of aromatic compounds.
- InertCore C8 Core-shell C8 for UHPLC/HPLC with moderate hydrophobicity, enabling fast, efficient, reproducible separations.
- InertCore Plus C18 Core-shell C18 for UHPLC/HPLC with superior reproducibility, durability, and sharp peaks.
- InertSustain C8 Ultra-inert C8 column for rapid analysis of hydrophobic compounds with symmetric peaks across a wide pH range.
- Inertsil C8 Ultra-pure silica C8 column for rapid analysis of hydrophobic compounds, ideal for legacy methods.
- InertSustainSwift C8 Ultra-inert C8 column for low-polarity analytes, peptides, and oligonucleotides with optimized 200Å pore size.
- Inertsil C8-3 Strong retentivity, very inert, and low back pressure, based on the same silica and bonding as Inertsil ODS-3.
- Inertsil WP 300 Wide-pore C8 column for rapid, high-resolution separation of proteins and peptides with sharper peaks.
- Inertsil C4 Low-retentivity C4 column for rapid analysis of highly hydrophobic compounds like fat-soluble vitamins.
- All C8 & C4 Columns visible-xs
- InertSustain Amide First choice for HILIC mode, offering the strongest retention of polar compounds with superior stability in water-rich conditions.
- Inertsil HILIC Diol-bonded HILIC column for excellent peak shape and strong retention of highly polar basic compounds.
- InertSustain NH2 First choice for sugar analysis, offering superior stability, reproducibility, and compatibility with weakly acidic eluents.
- Inertsil NH2 Aminopropyl column for sugar analysis, highly retentive in normal phase with superior stability and reproducibility.
- ProteoSil HILIC Bioseparation-focused HILIC column, excelling in hydrophilic compounds, peptide, glycan, and oligonucleotide analysis.
- All HILIC Columns visible-xs
- InertSustain PFP A pentafluorophenyl-modified column designed for enhanced separation of structurally similar compounds through multiple retention mechanisms, including π-π, dipole, and hydrogen bonding interactions.
- InertSustain Phenyl A directly bonded phenyl group gives the InertSustain Phenyl column unique reversed-phase selectivity, ideal for separating polar compounds and structural isomers via π-π and hydrogen bonding interactions.
- InertSustain Phenylhexyl A phenylhexyl-bonded column that offers complementary selectivity to traditional alkyl-chain columns, providing high inertness, reproducibility, and low back pressure.
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- InertSep C18 Silica sorbent with high end-capping, ideal for lipid removal & pesticide residue analysis.
- InertSep C18-ENV C18 sorbent with low end-capping, optimized for water analysis & anionic surfactant removal.
- InertSep HLB Versatile SPE column for extracting non-polar to highly polar compounds, with a wide pH range (1-14).
- InertSep C8 Silica sorbent with octyl groups, offering weaker retention than C18 for highly retained compounds.
- InertSep SCX Silica-based SPE column with strong cation exchange and non-polar interactions for enhanced retention.
- InertSep SAX Monofunctional C18 sorbent with medium end-capping, allowing secondary interactions for versatile use.
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- MonoSpin C18 High-permeability spin column for peptide desalting, drug extraction, and fast biological sample preparation.
- MonoSpin ProA Fast Protein A spin column for high-purity IgG antibody purification with >90% recovery.
- MonoSpin C18-CX Mixed-mode spin column with C18 and cation exchange for enhanced basic drug recovery.
- MonoSpin Phospholipid TiO₂/ZrO₂-coated spin column for efficient phospholipid removal and matrix effect reduction.
- MonoSpin SAX Strong anion exchange spin column for fast extraction of acidic drugs with high recovery.
- MonoSpin TiO TiO₂ spin column for phospholipid removal and organophosphorus pesticide purification.
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InertSep QuEChERS Kit High-purity extraction and cleanup kit for pesticide residue analysis in food and environmental samples.
Get the Right Column for Your Compound — InstantlyWhat compound are you analyzing? - GC Columns
- InertCap 1MS General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
- InertCap 1 General purpose, Hydrocarbons, PCBs, High Volatile solvents, Phenols
- InertCap 5MS/Sil General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 5MS/NP General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 5 General purpose, Halogenated compounds, Phenols, Pesticides, FAME
- InertCap 624MS Residual solvents of Pharmaceuticals, VOCs, Alcohols
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Get the Right Column for Your Compound — InstantlyWhat compound are you analyzing? - Instruments
LD249 Gas Leak Detector Compact, easy-to-use leak detector with thermal conductivity sensor for fast, accurate gas detection. Replaces the LD239.
FM4: Air Sampler for PFAS Low-volume air sampler for PFAS enabling comprehensive analysis of both gas and particle phases in a single sampling using stage-optimized materials.
Intelligent Pump UI-32 Series Next-generation dual-plunger HPLC pump with ultra-low pulsation and automated pressure control for flow chemistry.
OralChroma Halitosis Measuring Device High-precision breath analyzer using gas chromatography to quantify VSCs in 4 minutes — fast, reliable, and maintenance-free.
- LD249 Gas Leak Detector Latest model replacing LD239, with thermal conductivity detection for helium, hydrogen, and other gases.
GF1010 Digital Gas Flowmeter Portable, volumetric meter for accurate GC gas flow measurement without gas selection.
- Intelligent Pump UI-32 Series Next-generation dual-plunger HPLC pump with ultra-low pulsation and automated pressure control for flow chemistry.
Intelligent Micro Pump MP-32 Series Compact micro pump with ultra-low pulsation and high-pressure stability, ideal for flow chemistry and precision dosing.
Auto BPR BP-11 Auto Back Pressure Regulator for the UI-22 Series, maintaining stable pressure for consistent flow.
PCS Pump SP-32 Series Single plunger pump with real-time pressure control and low-pulsation flow—ideal for precise fluid delivery.- All HPLC Pumps visible-xs
Gastorr AG Series Reliable, CPU-controlled degassing system for low-flow applications with independent chamber design.
Gastorr BG Series High-performance degassing system with real-time vacuum display and independent chamber design.
Gastorr FG-42 Solvent degassing system optimized for fluorinated solvents with real-time vacuum display.
Gastorr PG Series High-flow degassing system for fractionating applications with real-time vacuum display.- All Degassing Units visible-xs
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- HPLC Columns
- Sample Preparation
- GC Columns
- Instruments
- LD249 Gas Leak Detector Compact, easy-to-use leak detector with thermal conductivity sensor for fast, accurate gas detection. Replaces the LD239.
- FM4: Air Sampler for PFAS Low-volume air sampler for PFAS enabling comprehensive analysis of both gas and particle phases in a single sampling using stage-optimized materials.
- Intelligent Pump UI-32 Series Next-generation dual-plunger HPLC pump with ultra-low pulsation and automated pressure control for flow chemistry.
- OralChroma Halitosis Measuring Device High-precision breath analyzer using gas chromatography to quantify VSCs in 4 minutes — fast, reliable, and maintenance-free.
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Mobile Phase Cleaner
Eliminate ghost peaks. Protect columns. Stabilize baselines.
Mobile Phase Cleaner is an in-line mobile-phase cleanup cartridge packed with high-purity activated carbon beads. Installed between the pump outlet and injector inlet, it captures trace organic contaminants from solvents, reagents/additives, and upstream LC components before they reach the injector, analytical column, or detector.
Because the cleaner is positioned before the injector, the injected sample does not pass through the sorbent. This allows the mobile phase to be cleaned without directly interacting with sample analytes.
By reducing mobile-phase-derived background, Mobile Phase Cleaner improves baseline stability, increases S/N ratio, and helps enable lower LOD/LOQ in trace-level analysis. High-pressure formats up to 120 MPa make it suitable for HPLC, UHPLC, and LC-MS workflows.
Key Benefits
- Cleaner baselines: Reduces ghost peaks and background originating from the mobile phase.
- Higher S/N: Lowers chemical background that can obscure low-level analytes.
- Trace analysis: Improved baseline stability supports more sensitive quantitation.
- Column protection: Reduces contaminant loading before the injector and analytical column.
- LC-MS ready: Designed for workflows where mobile-phase background limits sensitivity.
application notes for Mobile Phase Cleaner
See whether your compound has been run on this column. Each note gives the conditions and the chromatogram.
Specifications
Column format: Cartridge
Length: 20 mm, 30 mm, 50 mm, 75 mm
Inner diameter: 2.1 mm, 3.0 mm, 4.0 mm, 4.6 mm, 7.6 mm
Max Pressure: 120 MPa (1,200 bar), 60 MPa (600 bar), 20 MPa (200 bar)
Base gel: Active Carbon
Certificate of Analysis included with every analytical column
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About Mobile Phase Cleaner
Reduction of Mobile-Phase-Derived Ghost Peaks
Blank gradient chromatograms obtained with distilled water and acetonitrile as the mobile phases. Trace mobile-phase contaminants can accumulate on the analytical column during equilibration and elute as ghost peaks as the organic strength increases. Installing Mobile Phase Cleaner upstream of the injector substantially reduced these peaks, demonstrating effective removal of mobile-phase-derived organic contaminants.
The Mobile Phase Cleaner effectively removes UV-absorbing impurities derived from mobile phases, resulting in a cleaner baseline and reduced ghost peaks.
Without Mobile Phase Cleaner
With Mobile Phase Cleaner
Conditions
| Column | InertSustain AQ-C18, 3 µm, 100 × 3.0 mm I.D. |
| Mobile phase | A = Acetonitrile / B = Water |
| Gradient program | A = 0% (0 min) – 100% (30 min) |
| Flow rate | 0.6 mL/min |
| Column temperature | 40 °C |
| Detection | UV 210 nm |
Diclofenac Sodium Analysis
The Mobile Phase Cleaner removes interfering peaks, enabling more accurate quantification of diclofenac sodium.
Without Mobile Phase Cleaner
UV 280 nm
With Mobile Phase Cleaner
UV 280 nm
Comparison of diclofenac sodium analysis with and without Mobile Phase Cleaner
An interfering peak observed without Mobile Phase Cleaner is effectively removed after installation, resulting in a cleaner baseline and improved analytical reliability.
HPLC Flow Path and Installation Position
Mobile Phase Cleaner is installed in-line between the pump outlet and injector inlet to remove trace organic contaminants before they enter the injector and analytical column.
Accessories
| Descriptions | O.D. | I.D. | Length | Max. Press. | Cat. No. |
|---|---|---|---|---|---|
| Precut SS Tubing | 1/16" | 0.13 mm | 50 mm | >173.5 MPa (>25,160 psi) | 6010-33001 |
| 100 mm | 6010-33002 | ||||
| 200 mm | 6010-33003 | ||||
| 0.25 mm | 50 mm | 6010-33010 | |||
| 100 mm | 6010-33020 | ||||
| 200 mm | 6010-33030 | ||||
| Finger-Tight High-Pressure Fitting | Thumb Nut + Reusable Ferrule 10 sets | 50 MPa | 6010-77080 | ||
| UHPLC High-Pressure Fitting Set | Nut + Reusable Ferrule 10 sets | 140 MPa (20,300 psi) | 6010-77082 | ||
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