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InertCore C8

InertCore C8
InertCore C8

High-Performance Core-Shell C8 Columns for UHPLC and HPLC

In core-shell particles, analyte molecules pass through a thin porous shell surrounding a solid non-porous core. This structure significantly reduces diffusion within the particle compared to fully porous particles, resulting in sharper peaks and higher theoretical plate numbers.
Specifications
  • Base Material: Core-shell type silica gel
  • Functional group: Octyl (C8)
  • Particle size: 2.6 µm
  • End capping: Yes
  • Solid Core Size: 2.0 µm
  • Carbon loading: 10.0%
  • Surface area: 200 m2/g
  • USP Code: L1
  • Pore size: 90 Å (9 nm)
  • pH Range: 1.5 – 9
  • Max Operating Pressure: 100 MPa, 60 MPa
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InertCore C8

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About InertCore C8

 

Core-Shell Technology for Enhanced Column Efficiency

 

In core-shell particles, analyte molecules pass through a thin porous shell surrounding a solid non-porous core. This structure significantly reduces diffusion within the particle compared to fully porous particles, resulting in sharper peaks and higher theoretical plate numbers.

 
 
 

Advantages of Core-Shell Packing Material

Impact of Mobile Phase pH on Selectivity

 
  • Excellent particle size distribution minimizes multiple-path diffusion, enhancing efficiency and peak sharpness.
  • A 2.6 μm core-shell particle delivers a comparable number of theoretical plates to that of a sub-2 μm fully porous particle, but with the backpressure of a 3 μm fully porous column. 
  • The number of theoretical plates is increased by minimizing diffusion within the particle.

 
 
 

Superior Reproducibility

 

InertCore columns are subjected to rigorous in-house quality control, from raw silica synthesis to final inspection, ensuring outstanding batch-to-batch reproducibility through consistently uniform shell layers.

InertCore delivers exceptional batch-to-batch consistency, outperforming other core-shell columns in reproducibility.

SEM image

Particle size distribution

 
 
 

Specifications

Column InertCore Plus C18
Learn More 		InertCore C8
Learn More 		InertCore Biphenyl
Learn More

InertCore Plus C18 InertCore C8 InertCore Biphenyl
Base Material Core-shell type silica gel Core-shell type silica gel Core-shell type silica gel
Particle Size 2.6 µm 2.6 µm 2.6 µm
Solid Core Size 2.0 µm 2.0 µm 2.0 µm
Surface Area* 200 m²/g 200 m²/g 200 m²/g
Pore Size 90 Å (9 nm) 90 Å (9 nm) 90 Å (9 nm)
Functional Group Octadecyl (C18) Octyl (C8) Biphenyl
End-capping Yes Yes Yes
Carbon Loading* 15% 10% 10%
Recommended pH Range 1–10 1.5–9 1.5–8.5
USP Code L1 L7 L11
Max Pressure 100 MPa (2.1 mm I.D.)
60 MPa (3.0 / 4.6 mm I.D.)		 100 MPa (2.1 mm I.D.)
60 MPa (3.0 / 4.6 mm I.D.)		 100 MPa (2.1 mm I.D.)
60 MPa (3.0 / 4.6 mm I.D.)
 

*Value calculated for the porous layer only (core excluded).

Versatile Phase Selection for Optimized Separation

InertCore columns are available in C18, C8, and Biphenyl phases, allowing users to fine-tune retention and selectivity.

The comparative chromatograms highlight the differences in hydrophobic interaction and steric selectivity among these phases. Increasing the hydrophobicity of the column lengthens tha elution time of 6. n-Amylbenzene from that of 4. n-Butylbenzene. Increasing the steric selectivity of the column lengthens the elution time of 7. Triphenylene from that of 5. o-Terphneyl.

 
     
     
     

    Engineered for Stability and Consistency

    Exceptional Retention Time Stability

    InertCore Column exhibits remarkably stable retention times across multiple lots, as demonstrated by the hydrophobic retention test. This ensures reliable quantification and method transfer without the need for repeated revalidation, even when switching to a new column lot.

    Consistent Peak Shape for Basic Compounds Across Lots

    InertCore Plus C18 maintains excellent peak symmetry for strongly basic compounds across multiple production lots. The consistent surface treatment and high-quality bonding ensure minimal variation in peak shape and retention behavior, providing confidence in reproducibility and robustness for routine analyses.

     
     

    High Durability

    InertCore demonstrates excellent durability, maintaining retention time, Theoretical plates number, and peak symmetry even after 2,000 consecutive injections.

    *To eliminate the effect of system volume, plumbing size, etc. A general purpose HPLC system is optimized.

     
     

    Applications

     
     

    Nucleotide

     
    Chromatogram - Nucleotide
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 + 0.1% HCOOH in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    0.5 µL
    Analytes :
    1. Cytosine 2. Cytidine 3. Guanine 4. Adenine 5. Uracil 6. Uridine 7. Guanosine 8. Thymine 9. Adenosine 10. 5-Methyluridine
     
    (Nucleobase 25 mg/L each, Nucleoside 50 mg/L each)
     
     

    Cyclic Nucleotide cGAMP

     
    Chromatogram - Cyclic Nucleotide cGAMP
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    1 µL
    Analytes :
    1. cGMP 2. cAMP 3. 2,3-cGAMP
     
    (100 mg/L each)
     
     

    Nucleotide

     
    Chromatogram - Nucleotide
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 + 0.1% HCOOH in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    0.5 µL
    Analytes :
    1. Cytosine 2. Cytidine 3. Guanine 4. Adenine 5. Uracil 6. Uridine 7. Guanosine 8. Thymine 9. Adenosine 10. 5-Methyluridine
     
    (Nucleobase 25 mg/L each, Nucleoside 50 mg/L each)
     
     

    Cyclic Nucleotide cGAMP

     
    Chromatogram - Cyclic Nucleotide cGAMP
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    1 µL
    Analytes :
    1. cGMP 2. cAMP 3. 2,3-cGAMP
     
    (100 mg/L each)
     
     

    Nucleotide

     
    Chromatogram - Nucleotide
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 + 0.1% HCOOH in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    0.5 µL
    Analytes :
    1. Cytosine 2. Cytidine 3. Guanine 4. Adenine 5. Uracil 6. Uridine 7. Guanosine 8. Thymine 9. Adenosine 10. 5-Methyluridine
     
    (Nucleobase 25 mg/L each, Nucleoside 50 mg/L each)
     
     

    Cyclic Nucleotide cGAMP

     
    Chromatogram - Cyclic Nucleotide cGAMP
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    1 µL
    Analytes :
    1. cGMP 2. cAMP 3. 2,3-cGAMP
     
    (100 mg/L each)
     
     

    Guanine-based Antiviral Drugs

     
    Chromatogram - Guanine-based Antiviral Drugs
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    0.5 µL
    Analytes :
    1. Ganciclovir 2. Aciclovir 3. Penciclovir
     
    (100 mg/L each)
     
     

    Nucleoside-based Antiviral Drugs

     
    Chromatogram - Nucleoside-based Antiviral Drugs
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 220 nm
    Inj. Vol. :
    1 µL
    Analytes :
    1. Ribavirin 2. Cytarabine 3. Gemcitabine 4. Lamivudine
     
    (100 mg/L each)
     
     

    Decitabine

     
    Chromatogram - Decitabine
     

    Conditions

    Column :
    InertCore Biphenyl 2.6 µm, 100 × 2.1 mm I.D.
    Eluent :
    10 mM HCOONH4 in H2O
    Flow Rate :
    0.4 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 254 nm
    Inj. Vol. :
    0.5 µL
    Analytes :
    1. 5-Aza-2′-deoxycytidine (Decitabine) 2. Cytidine
     
    (100 mg/L each)
     
     

    Aldehydes

     
    Chromatogram - Aldehydes
     

    Conditions

    Column :
    InertCore Plus C18 2.6 µm, 150 × 4.6 mm I.D.
    Eluent :
    A) CH3CN
    B) H2O
    A/B = 50/50, v/v
    Flow Rate :
    1.5 mL/min
    Col. Temp. :
    40 °C
    Detection :
    UV 360 nm
    Inj. Vol. :
    10 µL
    Analytes :
    Reference Standard
     
    1. DNPH 2. DNPH-Formaldehyde 3. DNPH-Acetaldehyde
     
    (50 µg/L each in CH3CN)
     
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