The Most Deactivated Column Ever Made

GL Sciences’ newly-developed chemical bonding technology allows Inertsil ODS-4 to provide high efficiency and good peak shape where competitive columns fail. For example, in the example at right, Inertsil ODS-4 is compared with competitive ODS phases for the analysis of dextromethorphan, a basic compound. Where other columns show poor peak shape, often with secondary interactions that result in prolonged retention, Inertsil ODS-4 delivers symmetric peaks with high efficiency.

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Of course, chances are you probably won’t be analyzing dextromethorphan, so your question remains, “How will Inertsil ODS-4 help me with my sample?” Contact GL Sciences and let us arrange for you to evaluate Inertsil in your lab under your particular constraints, without risk (i.e. free of charge). We know you’ll be glad you tried this new technology.

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Dependable Excellence

GL Sciences’ Inertsil columns offer everything you need for your critical separations in all phases of drug development, and something less. Inertsil’s uniquely modified silicas and meticulously engineered column hardware allow our columns to operate at significantly lower back pressures than competitive columns, without sacrificing efficiency. Inertsil’s wide pH compatibility and excellent stability at elevated temperatures make it the ideal choice for your chromatography needs, whether you are using a traditional HPLC system or the latest rapid gradient LC/MS system with precise temperature control.

The Inertsil 3-series represents a major advance in performance over the original Inertsil 2-Series. Inertsil 3-Series phases are based on a purer, higher surface area silica which is specially manufactured to provide maximum bonded phase coverage. The result is a series of columns which provide excellent peak shapes using simple eluents while operating at low pressure.

In addition to ODS-3, we offer our new ODS-4, ODS-Sprint for reduced retention of non-polar compounds, C8-3, Phenyl-3, ODS-EP containing an embedded polar group for increased retention of polar compounds, CN-3, HILIC, NH2, Diol, and a Polymerically bonded ODS-P phase with unique selectivity for planar compounds, uniquely designed for analysis of 16 priority PAHs in environmental samples but has also found to be useful for pharmaceutical analysis of planar compounds. 

GL Sciences has compiled a vast collection of chromatographic applications data on ODS-3 and their other phases which can assist you in method development. 

Inertsil ODS-3, along with most of the other Inertsil 3-series phases, are available in 3, 5, and 8 micron particle sizes in column configurations ranging from capillary to 50mm ID preparative sizes.

By choosing Inertsil ODS-3, you can be assured that you are using one of the most trusted, popular, and enduring HPLC columns in the history of HPLC.

Need Extra Validation Data?

Inertsil ODS-3V offers all of the outstanding chromatographic benefits of Inertsil ODS-3 with the added benefit of a more thoroughly documented, validated QC procedure consistent with the demands of GLP/GMP compliance. Each Inertsil ODS-3V is delivered with a Manufacturer's Validation Certificate showing the detailed results of every QA and QC step in manufacturing.

The use of Inertsil ODS-3V columns provides an extra measure of assurance of consistent performance from column to column and batch to batch. Inertsil ODS-3V columns are also available in 3-column-sets packed with your choice of 3 different silica batches or a single silica batch to assist in reproducibility studies.

Embedded Polar ODS Phase

Inertsil ODS-EP contains a polar functional group embedded between the silica surface and the C18 group. The embedded polar group makes the C18 phase stable in 100% aqueous eluents without "phase collapse." This phase is also extremely "base deactivated" and provides superior peak shape for acids and bases in organic eluents as well as acidified eluents typically used in LC/MS. Inertsil ODS-EP is available in 5 micron particle size in column configurations ranging from capillary to 50mm ID preparative sizes.

ODS-SP for Increased Polar Retention

Inertsil ODS-Sprint is an important new addition to the renowned Inertsil HPLC column series. Inertsil ODS-Sprint is super base deactivated and optimally bonded to retain polar compounds without excessive retention of non-polar compounds, so you’ll achieve better separations faster than ever before. Like all GL Sciences’ advanced phases, ODS-Sprint operates at low back pressure even at high flow rates, shows outstanding longevity, and is endlessly reproducible, from column to column and batch to batch. To complement this outstanding new phase, GL Sciences’ created a zero-dead-volume column hardware format, known as Sprint-HG hardware, further enhancing peak symmetry.